Dosimetric Implications of Pulmonary Macrophage Clusters Observed Within Lungs of Rats That Have Inhaled Enriched U02 Particles

By Morris, Keith J.

Description
Government Reference Publication

Excerpt
Introduction: To satisfactorily assess the radiation dose to lung cells at risk of cancer induction, it is necessary to know the microscopic spatial distribution of the inhaled radioactive panicles within the lung tissues. This is particularly important for highly insoluble particles (International Commission on Radiological Protection [ICRP] Class Y), suchas plutoniumoxide (Pu0,)and uranium dioxide (UOJ that have long residence times in the lung. Data from animal studies suggest that such particles become increasingly less randomly distributed with time after inhalation (I) . In particular, the particles appear to become more associated with the lung periphery andperibronchial tissue (2.3). Diel et al. (4) speculate that this association may be due to preferential clearance of particles from the more central alveolar regions.

Book Id: WPLBN0000153722
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Reproduction Date: 2005

Title:

Dosimetric Implications of Pulmonary Macrophage Clusters Observed Within Lungs of Rats That Have Inhaled Enriched U02 Particles

Author:

Morris, Keith J.

Volume:

Language:

English

Subject:

Government publications, United Nations., United Nations. Office for Disarmament Affairs

Collection:

Disarmament Documents

Subcollection:

Historic
Publication Date:

Publisher:

United Nations - Office for Disarmament Affairs (UNODA)

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